USA AI Action Plan published

Dear Readers,

What happens when a superpower turns AI into a geopolitical weapon – and at the same time humanity is promised a longer, healthier life? In this issue, we take a look at two developments that not only mark technological progress, but also set the course for our social future: The new “America's AI Action Plan” signals a clear desire for global dominance through infrastructure, open source, and political pressure. At the same time, three medical breakthroughs show that the dream of extending life is becoming more tangible – not sometime in the future, but right now. We examine how the US plans to conquer global markets with strategic AI funding and open technologies – and what this means for Europe. Then we take you into the world of longevity research: from artificial mitochondria in a 90-year-old physicist to cell therapy that stops neurodegenerative diseases. The question remains: Will we use this technological change for the benefit of all, or will it become the exclusive advantage of a few? Be inspired and find out what is already possible today.

In Today’s Issue:

All the best,

The US is doing everything it can to expand its leadership role in the AI era—with a comprehensive, strategically thought-out action plan that sets new standards. At its core is the systematic expansion of infrastructure, easier access to computing power, and a massive commitment to open-source development. Start-ups, research, and industry are to be specifically promoted – while at the same time consolidating geopolitical power through AI technologies.

The “America's AI Action Plan” is based on three pillars: First, innovation will be accelerated through open access to code, computing, and data. Second, the physical infrastructure is to grow massively with new data centers, chip factories, and faster approval procedures. Third, Washington is aiming for global dominance: US AI models are to be exported as complete technology packages, while AI-hostile US states will be pressured with funding cuts. The plan offers enormous potential for developers and companies – but also raises controversial questions about surveillance, energy consumption, and ethics.

The plan rests on three strong pillars:

Why it matters: With its action plan, the US is sending a clear signal of its desire for technological dominance: open, scalable, and geopolitically calculated.

For the global AI landscape, this means a new dynamic between government control and free innovation.

Sources:

🔗 https://www.whitehouse.gov/wp-content/uploads/2025/07/Americas-AI-Action-Plan.pdf

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Cheers,

Acknowledging growing user sentiment, Google's Josh Woodward confirmed that the Gemini app has momentum and teased that there are many more updates to come.

“And of course there’s the revenue growth from providing highly valuable services to our customers + partners.”

— Sundar Pichai, CEO Alphabet

Researchers have discovered a combination of drugs that mimics the effects of calorie restriction—including the well-known fountain of youth effect. Initial human studies show promising signs of improved health and longer life – without extreme diets. This is relevant because it presents a practical, medicinal anti-aging tool. The future: anti-aging could become available over the counter – but clear long-term data is still lacking.

90-year-old physicist John G. Cramer is the first person to receive bioreactor-grown mitochondria in an experimental study—a radical approach to revitalizing cellular energy. What is new is that artificially produced mitochondria are transplanted directly into affected cells. Relevance: This milestone could restore age-related cell functions and revolutionize the field of mitochondrial therapy. In the future, targeted mitochondrial regeneration could lead to a real breakthrough in longevity medicine.

Clinical studies show that in eight ALSP patients—a rare, fatal form of leukoencephalopathy—the transplantation of healthy, CSF1R-competent microglia via bone marrow led to a complete halt in disease progression for at least 24 months. This is the first time that genetically defective immune cells have been successfully corrected directly in the brain, with stabilized cognitive and motor function. The success promises a revolutionary, cell-based therapy for neurodegenerative diseases – beyond ALSP, also conceivable for Alzheimer's and other conditions. In the future, targeted microglia repopulation could open up new ways to slow down the aging of the brain.

Working at the intersection of AI and human longevity? We’re inviting researchers and innovators to submit their work to be featured in Superintelligence, the leading AI newsletter with 200k+ readers.

Whether you’re using AI to extend lifespan, improve healthspan, or accelerate biomedical breakthroughs, email your arXiv.org link or a summary to [email protected] with the subject line “Longevity Submission”. If selected, we’ll contact you for a potential feature.

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