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Dear Readers,
As this newsletter continues to grow in popularity thanks to our loyal readership, we have decided to expand to other social media platforms and, above all, to offer more visual content. You can find daily AI bits on:
Threads 🔗 https://www.threads.com/@getsuperintel
YouTube 🔗 https://www.youtube.com/channel/UCWrhMixNbAMghzS-SNiA3Ug / @Superintel-daily
All by hand curated by “Chubby”.
Now onto todays News:
Each week, the frontier between biology and technology blurs a little more - and today’s stories prove how fast that fusion is accelerating. We’re looking at stem cells that reverse aging in monkeys, gene therapy that restores sight by targeting aging itself, and nanoparticles that repair the brain’s own defenses against Alzheimer’s. In AI, OpenAI’s watermark fight, Anthropic’s political backlash, and Sam Altman’s bold “AI empire” vision show a different kind of evolution; one where power, ethics, and compute intertwine. What ties it all together? A single question: how close are we to mastering the systems that once defined us?
In Today’s Issue:
⚡ Sam Altman details OpenAI's aggressive infrastructure bets and AI's potential for scientific discovery
🧠 Nanoparticles are reversing Alzheimer's in mice
👁️ Gene therapy is targeting retinal aging to combat dry age-related macular degeneration (AMD)
🐒 Chinese researchers successfully reversed aging in monkeys
✨ And more AI goodness…
All the best,
Sora 2 Watermarks Easily Removed
OpenAI’s Sora 2 video generator embeds a visual watermark (a cartoon-like cloud icon) to label AI-produced videos, but several web services already strip it effortlessly in seconds. Experts warn this undermines trust and may fuel the spread of scams, deepfakes, and disinformation. The moment when reality and fiction blur is now upon us.
Top AI Researcher Leaves Anthropic
Yao Shunyu, one of Anthropic’s standout researchers, has quit the company after it branded China an “adversarial nation” and blocked Chinese subsidiaries from using its models. He’s now joining Google DeepMind, saying he couldn’t stay with a firm taking such a hard political line. Once again, the battle between the companies is heating up.
Antibody Offers big Hope Against HIV
Early studies suggest the antibody 04_A06 could also help people who already have HIV, not just prevent infection. In mice with a human-like immune system, it drove the virus to undetectable levels for good — something no drug has fully achieved yet. Human trials haven’t begun, but scientists hope it could one day complement or even simplify current HIV treatments.
Sam Altman: "The Turing test sort of went whooshing by, which seemed long impossible ( it as this most important test of AI for a long time)", and after a week, everyone took it for granted.
The next step: The next big step: AI that conducts science independently, and we are
— #Chubby♨️ (#@kimmonismus)
7:44 AM • Oct 9, 2025
🚨 Veo 3.1 Updates
Video Length Extended to 1 Minute!
>Character Consistency
>Native 1080p output + fantastic Cinematic Presets.
>Multi-Prompting for Multi-Shot: >Easily generate a multi-scene story script from just a single image.— #Chetaslua (#@chetaslua)
9:54 PM • Oct 8, 2025
The Takeaway
👉 OpenAI is making "extremely aggressive" bets on infrastructure, signaling that the future of AI leadership will be determined by access to massive-scale computing power.
👉 Early signs from GPT-5 suggest that AI models will soon be capable of making significant scientific discoveries independently, accelerating research in fields like medicine and physics.
👉 The exponential growth of AI is intrinsically linked to the availability of cheap and abundant energy.
👉 The democratization of AI tools is lowering the barrier to entry for starting a company.
In a recent, insightful interview with Andreessen Horowitz (a16z), OpenAI CEO Sam Altman offered a captivating glimpse into his strategic thinking, revealing a vision for AI that extends far beyond the current hype. Altman’s ambitious roadmap is not just about building smarter models; it’s about fundamentally reshaping industries and accelerating scientific progress. He candidly discussed OpenAI's transformation from a research lab into a vertically integrated "AI empire" and emphasized the critical link between AI's exponential growth and the future of energy.
One of Altman's most compelling revelations was his excitement for "AI scientists"—AI systems capable of independent scientific discovery. He disclosed that early versions of GPT-5 are already showing nascent abilities in this area, making novel mathematical discoveries and small advances in physics and biology. This, he believes, will be a profound turning point for humanity. Altman also touched on the evolving landscape for entrepreneurs, noting that the rise of powerful AI tools has leveled the playing field, making it the best time in a decade for college dropouts and recent graduates to start companies.
Why it matters: Altman’s insights signal a strategic shift in the AI industry, where the race for dominance is no longer just about algorithms but about the entire ecosystem of computing power, capital, and energy. This vision, if realized, could unlock unprecedented scientific breakthroughs and create new opportunities for innovation across the board.
Sources:
🔗 https://www.youtube.com/watch?v=JfE1Wun9xkk&t=716s
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Nanoparticles Restore Brain Barrier, Reverse Alzheimer
Researchers engineered “supramolecular” nanoparticles that don’t target neurons directly but repair the blood-brain barrier, allowing the brain’s own waste-clearing mechanisms to resume and reduce toxic amyloid-beta build-up. In mouse models of Alzheimer’s, just three doses led to a 50–60 % drop in amyloid levels within an hour, and treated older mice regressed to behaviors seen in much younger, healthy animals. The key takeaway: restoring vascular integrity may be a more powerful therapeutic lever than attacking neurons head-on.
Gene Therapy Reverses Retinal Aging
Cirrus Therapeutics has raised $11 million in seed funding to develop a gene therapy for dry age-related macular degeneration (AMD) by restoring levels of the protein IRAK-M in the retina, thereby tackling aging and inflammation rather than just downstream damage. In preclinical models, replenishing IRAK-M protected against retinal degeneration—suggesting a possible one-time, durable treatment for vision loss. The big insight: targeting “aging itself” (via immune regulation in tissue) may unlock therapies for common, non-monogenic diseases like AMD.
Stem Cells Reverse Aging in Monkeys
This is so huge: Chinese researchers engineered senescence-resistant stem cells (SRCs) with an enhanced FOXO3 “longevity gene,” which rejuvenated aged monkeys across multiple organs and improved memory and brain connectivity without side effects! After 44 weeks of injections, over half of 61 tissues showed regeneration, inflammation dropped, and cognitive decline reversed.
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