
Dear Readers,
Every week, AI seems to leap closer to understanding life itself. This time, it’s not just about smarter models or faster benchmarks - it’s about machines uncovering hidden biological truths. Google’s Gemma model just hypothesized a new cancer treatment that worked in real-world lab tests. Meanwhile, China kept a 71-year-old alive with a genetically modified pig liver, and researchers discovered how the naked mole-rat’s DNA repair gene might hold clues to slowing human aging. The line between artificial and biological intelligence is getting thin enough to shimmer.
In today’s issue, we explore how Veo 3.1 is turning text into cinematic storytelling, Claude Haiku 4.5 is pushing affordable reasoning to new heights, and Qwen’s memory system is redefining what “personal AI” means. On the Longevity front, breakthroughs in xenotransplantation, gene editing, and molecular repair are reshaping medicine’s most ancient dream — defeating decay itself. Each story asks the same question: when intelligence learns to heal, what does progress look like? Dive in and decide for yourself.
In Today’s Issue:
🔬 Google's Gemma AI is acting as a scientific co-discoverer
🐷 Chinese doctors successfully transplanted a genetically modified pig liver
🧬 MIT researchers engineered a safer gene-editing variant (vPE)
🐀 A mole-rat gene that promotes DNA repair has shown the ability to reverse aging
✨ And more AI goodness…
All the best,



Veo 3.1 Revolutionizes Video Creation
Google DeepMind unveils Veo 3.1, a major leap in AI video generation with enhanced realism, storytelling intelligence, and new creative tools. The update introduces features like multi-image scene integration, minute-long clip extensions, and “first-to-last-frame” transitions for seamless storytelling.

Claude Haiku 4.5 released
Anthropic introduces Claude Haiku 4.5, a compact AI model delivering Sonnet 4–level performance at one-third the cost and over twice the speed. Benchmark results show exceptional versatility across coding, reasoning, and math tasks, with near-perfect scores in compute use and HumanEval. Now available via API, Amazon Bedrock, and Google Cloud Vertex AI, Haiku 4.5 positions itself as a fast, affordable, and powerful sub-agent option for complex AI workflows.

Qwen Introduces Personalized AI Memory
Alibaba’s Qwen unveils “Chat Memory,” a new feature that remembers user context and past interactions to create more personal, adaptive conversations. It stores meaningful details, recalls relevant moments, and uses this memory to shape future responses, offering a seamless, tailored AI experience. The update marks a major step toward emotionally intelligent and context-aware chat systems.

Anthropic released Claude Haiku 4.5. Here is the introduction to their new model.

OpenAI clarified that the upcoming ChatGPT changes aim to give adult users more freedom while keeping strict protections for minors. The company emphasized it doesn’t want to act as “moral police” but rather to mirror real-world boundaries like age ratings for movies.
Ok this tweet about upcoming changes to ChatGPT blew up on the erotica point much more than I thought it was going to! It was meant to be just one example of us allowing more user freedom for adults. Here is an effort to better communicate it:
As we have said earlier, we are
— #Sam Altman (#@sama)
7:11 PM • Oct 15, 2025

BREAKING 🚨: First mention of Gemini 3.0 Pro has been spotted on Gemini!
"We've upgraded you from the previous model to 3.0 Pro, our smartest model yet."
— #TestingCatalog News 🗞 (#@testingcatalog)
7:41 PM • Oct 15, 2025


The Takeaway
👉 Google’s 27B-parameter Gemma model uncovered a novel immune-boosting mechanism involving silmitasertib.
👉 The finding demonstrates emergent reasoning — AI forming testable biological hypotheses from data alone.
👉 Open-source Gemma models invite others to reproduce and extend such scientific breakthroughs.
👉 Marks a turning point: AI moves from assistant to scientific collaborator in biomedical research.
It started with a whisper in single-cell data — and now Google’s Gemma AI has proposed a brand-new cancer therapy pathway that real-world lab tests confirmed. Using a 27-billion-parameter foundation model called Cell2Sentence-Scale (C2S-Scale), developed in collaboration with Yale University, researchers challenged the model to find drugs that could boost immune signaling only in tumor environments already activated by interferon. The AI zeroed in on silmitasertib, a CK2 inhibitor, predicting it would amplify antigen presentation in precisely those contexts. When tested in vitro, the prediction held true — showing a roughly 50 % stronger immune response than controls.

What makes this special is that the model didn’t just analyze data; it generated a new biological hypothesis — one that scientists could actually validate. That marks a subtle but profound shift: from AI as a helper to AI as a co-discoverer. For the research community, it’s a glimpse into how foundation models could soon accelerate drug discovery far beyond human intuition.

Why it matters: Because this experiment shows that AI can discover biological mechanisms, not merely predict them.
Because it opens a path to faster, cheaper, and more creative medical breakthroughs.
Sources:

How 1,500+ Marketers Are Using AI to Move Faster in 2025
Is your team using AI like the leaders—or still stuck experimenting?
Masters in Marketing’s AI Trends Report breaks down how top marketers are using tools like ChatGPT, Claude, and Breeze to scale content, personalize outreach, and drive real results.
Inside the report, you’ll discover:
What AI use cases are delivering the strongest ROI today
How high-performing teams are integrating AI into workflows
The biggest blockers slowing others down—and how to avoid them
A 2025 action plan to upgrade your own AI strategy
Download the report. Free when you subscribe to the Masters in Marketing newsletter.
Learn what’s working now, and what’s next.


ArtificialAnalysis leaderboard


China’s Pig Liver Transplant Breakthrough
In a medical first, Chinese doctors successfully transplanted a genetically modified pig liver into a living 71-year-old patient, who survived 171 days — 38 of them supported by the pig organ. The liver, engineered to reduce immune rejection, maintained several human metabolic functions, marking a major step for xenotransplantation. This breakthrough could ease the global organ shortage and open the door to “bridge organs” that sustain patients while awaiting human transplants.

Safer Gene Editing Breakthrough Emerges
MIT researchers have engineered a new variant of prime editing (vPE) that reduces unintended DNA edits by up to ~60-fold compared to prior systems, without complicating delivery or adding extra steps. By combining modified Cas9 proteins and more stable RNA templates, the team achieved error rates as low as 1 in 101–543 edits in human and mouse cells. This advance raises the bar for safer gene therapies and nudges us closer to precise correction of age-related genetic damage.

Mole-Rat Gene Rewrites Human Aging
New study finds that naked mole-rats’ version of the DNA sensor cGAS has four key amino acid changes that turn it from a suppressor to a promoter of DNA repair; this allows them to better stabilize their genomes, resist cellular aging, and extend health-span. When this mole-rat cGAS was put into human, mouse, and even fruit fly cells, DNA repair improved and aging markers dropped. This hints we might someday reprogram our own repair machinery for longevity.




